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UK Pathology Postdoctoral University of Oxford January 2013

We suggested that transcription occurs in discrete 'factories' that contain high local concentrations of the machinery required to make a transcript. Our primary aim here is to characterise the genes and transcripts associated with factories in human cells (using high-throughput sequencing and 'super-resolution' localization). We wish to (i) analyse how their contents change when two medically-important cytokines (TNFalpha, TGFbeta) activate responsive genes, (ii) characterise a sub-set of factories producing the micro-RNAs that act as immediate effectors, and (iii) use a zinc-finger nuclease to insert different test sequences at one specific site in the genome to see how they modify local and global gene activity.

Applicants should have an excellent background in cell and molecular biology, a PhD or equivalent in a relevant subject, sound mathematical and computational skills and demonstrable ability to collaborate on shared projects.

The closing date for applications is midday on 2 January 2013.

Applicants should have an excellent background in cell and molecular biology, a PhD or equivalent in a relevant subject, sound mathematical and computational skills and demonstrable ability to collaborate on shared projects.

*2 January 2013

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form