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Name of scholarship/program

Investigating the Dynamic Regulation of P2X4/7 receptors under shear stress at arterial sites prone to atherosclerosis

Important description
Cardiovascular disease is the leading cause of mortality globally. Arterial plaque formation occurs at prone sites within the artery where disturbed flow promotes inflammatory activation of endothelial cells (EC), facilitating leukocyte and lipoprotein infiltration into the vessel wall. Normal laminar flow maintains EC in a quiescent state, protecting the vessel wall from atheroma formation. EC express the ATP-gated ion channels P2X4 and P2X7 receptors, which may act together to activate inflammatory responses. In this project you will investigate whether disturbed “atheroprone” flow dynamically regulates endothelial P2X4/7 responses, improving our understanding of how the endothelium becomes susceptible to plaque formation, and providing potential targets for disease intervention.
We are seeking a highly motivated and excellent individual with a strong commitment to research. You will gain experience in scientific training including presenting your findings at meetings and in papers. You will master a number of primary cell isolation and culture techniques, molecular biology, functional techniques including imaging and fluorimetry, pharmacological testing, in situ hybridization and immunohistochemistry of human tissue samples.

Funding Notes:

Entry Requirements:
Candidates must have a first or upper second class honors degree or significant research experience.

Interested candidates should contact Dr Heather Wilson. (H.L.Wilson@sheffield.ac.uk).

This prestigious British Heart Foundation studentship is available to UK/EU candidates only. The studentship funds a stipend of £19,339-£21,321 per year and fees at the UK/EU rate.

Complete a University Application form and attach at least two references to your application. To complete the application form please visit: www.shef.ac.uk/postgraduate/research/apply.

Please state the prospective main supervisor in the respective box and select ‘Medicine’ as the department.

Eligibility and other criteria
Funded PhD Project (European/UK Students Only)
This research project has funding attached. Funding for this project is available to citizens of a number of European countries (including the UK). In most cases this will include all EU nationals. However full funding may not be available to all applicants and you should read the full department and project details for further information.

Application deadline
Applications accepted all year round

Additional information, and important URL

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