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Name of scholarship/program

PhD fellowship at CIC biomaGUNE, San Sebastian, Spain: the development of new methodology for the synthesis of glycan mimetics, multivalent constructs and their biomedical evaluation in functional immune assays



Important description
Applications are invited for 36 month position as early-stage researcher (ESR) to work on the Marie Sk?odowska-Curie Innovative Training Network IMMUNOSHAPE (Selective Carbohydrate Immunomodulators targeting C-type Lectin Receptors on Antigen Presenting Cells). Grant Agreement nᄎ: 642870.

The research project, which will be carried out in the Glycotechnology group headed by Dr. Niels-Christian Reichardt at CIC biomaGUNE, San Sebastian, (Spain), will address the development of new methodology for the synthesis of glycan mimetics, multivalent constructs and their biomedical evaluation in functional immune assays. The project will interface the chemical synthesis of glycans and glycomimetics, surface science, nanotechnology and mass spectrometry to prepare novel tools for the preparation, presentation and analysis of biomedically relevant glycans.

The project implies a series of secondments at partner labs in Germany, the Netherlands and Italy for additional training.
The successful candidate will participate in the networkメs training activities and work placements at the laboratories of the participating academic and industrial teams. Regular meetings and workshops within the EU-funded IMMUNOSHAPE International Training Network will supplement the training and support provided at CIC biomaGUNE.

IMMUNOSHAPE is a major EU funded programme which brings together 13 leading European partners in a transnational network, implementing a multidisciplinary and intersectorial research and training programme between the academic and the industrial partners in the fields of biomedical glycoscience. IMMUNOSHAPE aims at training a new generation of scientists that will be capable of combining state of the art synthesis and screening technology to develop new lead structures for highly selective glycan based multivalent immunotherapeutics for the treatment of cancer, autoimmune diseases and allergy.

The ESR will be contractually employed by CIC biomaGUNE and will be covered under the social security scheme. He or she will receive a Monthly Living Allowance plus a Mobility Allowance compliant with the applicable EC Marie Sk?odowska-Curie Actions-ITN general conditions.


Eligibility and other criteria
ユ Have an excellent Diploma and/or a Master Degree in Chemistry and a well-founded background with hands-on experience in chemical organic synthesis, ideally in carbohydrate synthesis
ユ Additional experience and knowledge in materials science, mass spectrometry or nanotechnology highly welcome
ユ Have less than 4 years research experience at the signature of the contract (measured from the time the Masterメs degree has been obtained).
ユ Not have a PhD already.
ユ Not have resided or carried out main activity in Spain for more than 12 months in the last 3 years immediately prior to the reference recruitment date.
ユ Excellent knowledge of the English language (spoken and written / proficiency level)


Application deadline
* March 1, 2015


Additional information, and important URL
http://www.cicbiomagune.es/

Candidates should submit a CV, cover letter and the names and contact details of at least 3 references by e-mail to rrhh@cicbiomagune.es indicating reference nᄎ 3021 in the subject.

References:
Nanostructured ITO slides for Small Molecule Profiling and Imaging Mass Spectrometry of Metabolites and by SALDI-MS. Lopez de Laorden C., Beloqui A., Yate L., Calvo J., Puigivila M., Llop J. and Reichardt N.C.; Anal. Chem. 0, 10.1021/ac5025864 (2014).

Biological Evaluation of Multivalent Lewis X-MGL-1 Interactions. Eriksson M., Serna S., Maglinao M., Schlegel M.K., Seeberger P.H., Reichardt N.C. and Lepenies B.; ChemBioChem 15, 844 - 851 (2014).

Analysis of Microarrays by MALDI-TOF MS. Beloqui A., Calvo J., Serna S., Yan S., Wilson I. B. H, Martin-Lomas M. and Reichardt N.C.; Angew. Chem. Int. Ed. 52, 7477 -7481 (2013).

Glyconanotechnology. Reichardt N.C., Mart�n-Lomas M. and Penad�s S.; Chem. Soc. Rev. 42, 4358-4376 (2013).

Three-Dimensional Arrays Using GlycoPEG Tags: Glycan Synthesis, Purification and Immobilisation. Etxebarria J., Serna S., Beloqui A., Martin-Lomas M. and Reichardt N.C.; Chem. Eur. J. 19, 4776-4785 (2013).

Fucosyltransferases as Synthetic Tools: Glycan Array Based Substrate Selection and Core Fucosylation of Synthetic N-Glycans. Serna S., Yan S., Martin-Lomas M., Wilson I.B.H and Reichardt N.C.; J. Am. Chem. Soc. 133, 16495-16502 (2011).

MALDI-TOF Mass Spectrometric Analysis of Enzyme Activity and Lectin Trapping on an Array of N-Glycans. Sanchez-Ruiz A., Serna S., Ruiz N., Martin-Lomas M., and Reichardt N.C.; Angew. Chem. Int. Ed. 50, 1801-1804 (2011).

http://www.cicbiomagune.es/


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