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Dynamic Microtubules in Directed Cell Migration

Important description
During cell migration, assembly of actin filaments generates the forces necessary for protrusion at the cell front, actin-myosin contraction drives retraction of the cell rear. Integrin-containing adhesion complexes mediate transmission of these forces to the extracellular substrate and allow forwards movement. Microtubules are not directly involved in force-generating or transmitting processes, but control the asymmetry of these processes and the polarisation of the cell.

We know that the presence of dynamic microtubules in the vicinity of a protruding cell cortex is required to stabilise protrusion and allow it to continue. However, the molecular mechanisms by which microtubules regulate cell protrusion remain to be understood. We know a number of factors that co-regulate microtubule and actin dynamics and this project will explore the function of actin-microtubule co-regulators in directional cell migration.

You will work in the laboratory of Anne Straube in the Division of Biomedical Cell Biology at Warwick Medical School. The group is based in the Mechanochemical Cell Biology Building; a purpose-built laboratory housing a number of research groups interested in cellular self-organisation, the cytoskeleton and molecular motors as well as state-of-the-art facilities for live cell imaging and image analysis. You will be trained in molecular biology, biochemistry and quantitative live cell imaging approaches.

Eligibility and other criteria
You should hold or expect to achieve a 1st or high upper 2nd class BSc degree and ideally an MSc with merit or distinction in a relevant field. Experience of using microscopy to study cell biological processes, quantitative analysis of imaging data and biochemical/biophysical assays to study protein-protein interactions in vitro is desirable. Knowledge of JAVA and/or Matlab programming is also desirable.

Application deadline
* Applications accepted all year round

Additional information, and important URL

For initial contact, please send a covering letter (including a statement of career intentions) with a full CV (including list of publications), degree certificates or transcripts plus two academic references to Dr Straube (a.straube@warwick.ac.uk).

Funding Notes:
Students will be expected to apply for a PhD scholarship from their home country or for a Chancellor's PhD scholarship ( http://www2.warwick.ac.uk/services/academicoffice/gsp/scholarship/typesoffunding/phd/chancellorsinternationalscholarships ). Note application deadline for Chancellor's studentships are in early January for entry in October.

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