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European Students Only May 2013 University of Nottingham PhD Research Project School of Biosciences Funded PhD Project UK Students Only

The embryonic root initially forms as a radially symmetric organ. The specification of xylem cells generates the positional information to create bilateral symmetry. This is coordinated by small differences in the spatial response patterns of two hormones, auxin and cytokinin. Using the model plant Arabidopsis, we have identified a mutually inhibitory interaction that sets vascular pattern. In this mechanism auxin directly promotes the expression of the cytokinin signalling inhibitor AHP6 and (through an unknown mechanism) cytokinin regulates the activity of the PIN class of auxin transporters.

The successful applicant will investigate the mechanism through which cytokinin regulates the activity of one of the PIN proteins, PIN7. The applicant will use a combination of genomic tools (including microarrays and yeast one hybrid screens) alongside a genetic screen to identify novel cytokinin-dependent factors regulating PIN7.

This project will be based at the Centre for Plant Integrative Biology, a world-renowned centre for plant biology with state of the art equipment. We are taking an interdisciplinary approach to investigating root vascular patterning and combine experimental biology with mathematical modelling of vascular patterning. A suitable candidate will have good communication skills and be willing to work in an interdisciplinary team. Applicants are required to have the equivalent of a 2(i) class degree in biology (or related subject) and a desire to research plant development. Experience in some of the following areas would be desirable; plant science, molecular biology, genomics or microscopy. The position is advertised to start in September 2013 but could start earlier.

This research project has funding attached. Funding for this project is available to citizens of a number of European countries (including the UK). In most cases this will include all EU nationals. However full funding may not be available to all applicants and you should read the full department and project details for further information.

*31 May 2013

Award Start Date:





1st September 2013





Duration of Award