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MRC: Functional analysis of mice with targeted deletion of a gene newly-implicated in schizophrenia



Important description
This MRC funded project provides students with cutting-edge research opportunities in Medical Research. Projects will align with MRC strategic priorities, www.mrc.ac.uk

Schizophrenia is a common and severely debilitating disease with a strong genetic influence. We have recently found that a gene involved in glutamatergic signalling - MAP2K7 –shows a strong genetic association with schizophrenia. This projectaims to test the hypothesis that the MAP2K7 gene plays a causal role in neurochemical and cognitive processes that are compromised in schizophrenia. The project will focus on testing for schizophrenia-related phenotypes in mice with a genetic deletion of the Map2k7 gene, as compared to control mice. A variety of technical approaches will be used. Neurochemical and molecular techniques will include RT-PCR, in situ hybridisation and immunohistochemistry. Behavioural techniques will include working memory and attentional tasks. The project aims to answer three related questions:

1) Does Map2k7 deficiency produce the neurochemical changes characteristic of schizophrenia (glutamatergic and GABAergic deficits in the prefrontal cortex and hippocampus) ?
2) Does Map2k7 interact functionally with other schizophrenia risk genes (neuregulin, dysbindin), and does Map2k7 deficiency impair glutamatergic signalling ?
3) Does Map2k7 deficiency produce behavioural changes characteristic of schizophrenia (deficits in working memory and attentional processing) ?

It is anticipated that the results will provide new insight into the aetiology of key functional deficits in schizophrenia. The project may also identify a new translational model for schizophrenia. In addition, the project will provide training in a wide range of techniques that are currently a major focus of research activity.

Visit our website for more information: http://www.gla.ac.uk/colleges/mvls/graduateschool/researchopportunities/scholarshipopportunities/medicalresearchcouncil/#tabs=0

Applicant Instructions

These are 3.5-year PhD studentships and students should apply online here: http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/

Applicants will normally be expected to reside (or have residency) within the UK. EU nationals will have to demonstrate that they have spent the three years prior to application resident in the UK (this can include residence whilst undertaking undergraduate study). Applicants should have obtained, or expect to obtain a 2:1 or 1st class Honours degree in a relevant subject. The financial package will include a 3.5 year stipend, approved University fees, Research Training Support Grant and a conference allowance.

On the Programme of Study section of the application please select “MVLS PhD” from the drop down menu. On this same page please place the project title(s) within the free text area and note the project supervisor(s).

Please ensure that all supporting documents are uploaded at point of application, for example:

- Copy of Academic and Professional qualifications
- CV (including letter of application/personal statement)
- 2 x references

Further supporting documents are requested on the online applications system, and should be uploaded where relevant. General enquiries regarding the programme and application procedure should be directed to Alexis Merry: Alexis.Merry@glasgow.ac.uk


Eligibility and other criteria
This research project has funding attached. Funding for this project is available to citizens of a number of European countries (including the UK). In most cases this will include all EU nationals. However full funding may not be available to all applicants and you should read the full department and project details for further information.


Application deadline
*06 May 2013


Additional information, and important URL
http://www.findaphd.com/common/clickCount.aspx?theid=36627&type=75&url=http%3a%2f%2fwww.gla.ac.uk%2fresearch%2fopportunities%2fhowtoapplyforaresearchdegree%2f""
http://www.FindAPhD.com/search/EmailEnquiry.aspx?fapjid=36627&LID=559&EA=Alexis.Merry@glasgow.ac.uk"">Alexis.Merry@glasgow.ac.uk
http://www.findaphd.com/common/clickCount.aspx?theid=36627&type=75&url=http://www.mrc.ac.uk""
http://www.findaphd.com/common/clickCount.aspx?theid=36627&type=75&url=http%3a%2f%2fwww.gla.ac.uk%2fcolleges%2fmvls%2fgraduateschool%2fresearchopportunities%2fscholarshipopportunities%2fmedicalresearchcouncil%2f%23tabs%3d0""
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/
http://www.gla.ac.uk/colleges/mvls/graduateschool/researchopportunities/scholarshipopportunities/medicalresearchcouncil/#tabs=0

Deadline: Rolling selection process. First round application closing date: May 6. Second round closing date: July 1
Stipend: £13,726 per annum
Start date: October 2013

This MRC funded project provides students with cutting-edge research opportunities in Medical Research. Projects will align with MRC strategic priorities, http://www.findaphd.com/common/clickCount.aspx?theid=36627&type=75&url=http://www.mrc.ac.uk"" target=""_blank"" rel=""nofollow"">www.mrc.ac.uk

Schizophrenia is a common and severely debilitating disease with a strong genetic influence. We have recently found that a gene involved in glutamatergic signalling - MAP2K7 –shows a strong genetic association with schizophrenia. This projectaims to test the hypothesis that the MAP2K7 gene plays a causal role in neurochemical and cognitive processes that are compromised in schizophrenia. The project will focus on testing for schizophrenia-related phenotypes in mice with a genetic deletion of the Map2k7 gene, as compared to control mice. A variety of technical approaches will be used. Neurochemical and molecular techniques will include RT-PCR, in situ hybridisation and immunohistochemistry. Behavioural techniques will include working memory and attentional tasks. The project aims to answer three related questions:

1) Does Map2k7 deficiency produce the neurochemical changes characteristic of schizophrenia (glutamatergic and GABAergic deficits in the prefrontal cortex and hippocampus) ?
2) Does Map2k7 interact functionally with other schizophrenia risk genes (neuregulin, dysbindin), and does Map2k7 deficiency impair glutamatergic signalling ?
3) Does Map2k7 deficiency produce behavioural changes characteristic of schizophrenia (deficits in working memory and attentional processing) ?

It is anticipated that the results will provide new insight into the aetiology of key functional deficits in schizophrenia. The project may also identify a new translational model for schizophrenia. In addition, the project will provide training in a wide range of techniques that are currently a major focus of research activity.

Visit our website for more information: http://www.findaphd.com/common/clickCount.aspx?theid=36627&type=75&url=http%3a%2f%2fwww.gla.ac.uk%2fcolleges%2fmvls%2fgraduateschool%2fresearchopportunities%2fscholarshipopportunities%2fmedicalresearchcouncil%2f%23tabs%3d0"" target=""_blank"" rel=""nofollow""> http://www.gla.ac.uk/colleges/mvls/graduateschool/researchopportunities/scholarshipopportunities/medicalresearchcouncil/#tabs=0

Applicant Instructions

These are 3.5-year PhD studentships and students should apply online here: http://www.findaphd.com/common/clickCount.aspx?theid=36627&type=75&url=http%3a%2f%2fwww.gla.ac.uk%2fresearch%2fopportunities%2fhowtoapplyforaresearchdegree%2f"" target=""_blank"" rel=""nofollow""> http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/

Applicants will normally be expected to reside (or have residency) within the UK. EU nationals will have to demonstrate that they have spent the three years prior to application resident in the UK (this can include residence whilst undertaking undergraduate study). Applicants should have obtained, or expect to obtain a 2:1 or 1st class Honours degree in a relevant subject. The financial package will include a 3.5 year stipend, approved University fees, Research Training Support Grant and a conference allowance.

On the Programme of Study section of the application please select “MVLS PhD” from the drop down menu. On this same page please place the project title(s) within the free text area and note the project supervisor(s).

Please ensure that all supporting documents are uploaded at point of application, for example:

- Copy of Academic and Professional qualifications
- CV (including letter of application/personal statement)
- 2 x references

Further supporting documents are requested on the online applications system, and should be uploaded where relevant. General enquiries regarding the programme and application procedure should be directed to Alexis Merry: http://www.FindAPhD.com/search/EmailEnquiry.aspx?fapjid=36627&LID=559&EA=Alexis.Merry@glasgow.ac.uk"">Alexis.Merry@glasgow.ac.uk


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