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Name of scholarship/program

Investigating the biological role of i-Motif DNA structures



Important description
In addition to the classical B-form double helix, DNA can adopt many different secondary structures. Sixty nine percent of all known oncogenes contain GC rich sequences in their promoter regions that can adopt DNA secondary structures such as G-Quadruplexes and i-Motifs. G-quadruplex structures have been shown to exist in vivo and stabilisation of these structures can silence genes. Targeting such structures with small molecules has been proposed as therapeutic strategies that could prevent cancer progression and development. Given that i-Motifs will form opposite G-quadruplexes, these secondary structures may also play a key role in protein recognition; offering an alternative drug-design target. Currently very little is known about the biological effects of i-Motif structures. This project will improve understanding of their effects in vivo.

Minimum entry requirements: 2:1 in Biological Sciences, Biochemistry, Pharmacy, Chemistry


Eligibility and other criteria
Self-Funded PhD Students Only
If you have the correct qualifications and access to your own funding, either from your home country or your own finances, your application to work with this supervisor will be considered.


Application deadline
* 01 March 2013


Additional information, and important URL


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