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PhD Position in bacterial genetics and Salmonella infection biology



Important description
The Helmholtz Young Investigator Group “Infection Biology of Salmonella” studies molecular mechanisms of virulence and type-III secretion using the Gram-negative pathogen Salmonella enterica.

Project: Salmonella are motile, gram-negative, intracellular pathogens that infect mammalian cells. Outbreaks of salmonellosis are a great economic and health problem worldwide. Many bacteria, like Salmonella, swim through liquid environments by rotating a helical organelle, the flagellum. This sophisticated nanomachine is functionally and structurally related to the virulence-associated type-III secretion systems (T3SS) of pathogenic bacteria. The ability to move is of crucial importance for Salmonella virulence and infection of eukaryotic cells. The aim of this project is to study the mechanisms of bacterial motility during bacteria-host interactions and the molecular function of bacterial T3SS. Understanding the fundamental, molecular mechanisms of Salmonella virulence will contribute to the development of new strategies that interfere with pathogen infections. Methods will include a combination of sophisticated bacterial genetics, microscopy, biochemistry and infection biology techniques.


Eligibility and other criteria
Master’s Degree/Diploma in Biology, Biochemistry, Bioinformatics, Biotechnology, Life Sciences or related fields
Experience in molecular biology, microscopy and/or genetics will be considered as an advantage
Ability to work independently and as part of an international team
High motivation and excellent English communication skills (written and spoken)


Application deadline
* 15.11.2012


Additional information, and important URL
Equal Opportunities is part of our personnel policy - qualified women are especially invited to apply. With equal professional qualification, severely disabled persons will be prioritized.

Starting date: 01.02.2013 - Iinitial contract for 3 years -
Salary: TVöD E13 (65%)
Probation period: 6 months
Closing date: 15.11.2012


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