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Mouse models Genetics Position is available immediately PhD University of Göttingen Membrane Cell culture DNA technologies

A PhD position is available immediately in the Department of Clinical Pharmacology at the University of Göttingen.
The Project
Carrier mediated membrane transport may limit the distribution and the metabolism of drugs in our body. The membrane transporter OCT1 is strongly expressed in the sinusoidal membrane of hepatocytes and may limit the uptake of drugs in the liver. OCT1 is highly genetically variable. Due to common genetic variants 9% of the German population lack OCT1 activity and have altered pharmacokinetics of drugs like morphine, tropisetron and tramadol. The aim of the PhD project will be to identify new drugs, which pharmacokinetics and efficacy is altered by the lack of OCT1, to characterize newly identified and to analyze the substrate specificity of existing OCT1 variants.

The methods that will be used in the project:

analyses of membrane transport in genetically engineered cell lines and transgenic mouse models
analyzing effects of genetic polymorphisms on drug pharmacokinetics and efficacy in mouse models and in humans
collection of human liver samples and analyses of genetic polymorphisms and gene expression using real-time PCR
promoter analyses using ChIP, electrophoretic mobility shift and reporter gene assays

We are looking for a highly motivated candidate with a master’s degree (or equivalent) in molecular biology, biology, or molecular medicine. Experience with cell culture, mouse models, recombinant DNA technologies, or analysis of transcriptional regulation will be an advantage.

Position is available immediately

a scholarship in the DFG-sponsored graduate school GRK 1034
an opportunity to work in a well-equipped molecular and cell biology laboratory
a long-lasting experience in the fields of pharmacogenetics and drug transport
Furthermore, a successful doctorate in the field of clinical pharmacology will prepare the candidate for exciting job opportunities in both academia and the pharmaceutical industry.

Applications should be addressed to Dr. Mladen V. Tzvetkov, University of Göttingen, Department of Clinical Pharmacology, email: mtzvetk@gwdg.de.

The University of Göttingen is an equal opportunity employer and places particular emphasis on fostering career opportunities for women. Qualified women are therefore strongly encouraged to apply. Disabled persons with equivalent aptitude will be favored.